If you expect the best of the best, enjoy outstanding service and experience luxury like no other in South San Francisco 5-star properties. Find the best deals and unwind in style at iconic five star hotels in South San Francisco. These world class South San Francisco hotels offer luxurious accommodations with premium locations. Check out this list of South San Francisco ultra-opulent hotels to pamper yourself. From modern to classic the South San Francisco area hotels offer something for your specific liking.